Description

Dde-D-Orn(Fmoc)-OH is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling complex, multi-step peptide assembly by providing selective deprotection strategies, thereby enhancing synthesis efficiency and purity. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptide-based diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of complex peptide chains, particularly where orthogonal protecting group strategies are required.
• Pharmaceutical Research & Development: For the synthesis of novel peptide drug candidates, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify bioactive peptide leads.
• Bioconjugation and Probe Development: Enables the site-specific attachment of labels, tags, or other molecules to peptides for diagnostic or imaging applications.
• Academic & Institutional Research: Fundamental tool in biochemistry and molecular biology labs studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech industry.

Basic Information

Product Name	Dde-D-Orn(Fmoc)-OH
CAS No.	2044710-31-6
Molecular Formula	C₂₇H₃₁N₃O₆
Molecular Weight	493.55 g/mol
Synonyms	Fmoc-D-Orn(Dde)-OH; Nδ-(1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-Nα-(9-fluorenylmethoxycarbonyl)-D-ornithine; (2R)-5-[[2-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; N-α-Fmoc-N-δ-Dde-D-ornithine; Dde-D-Ornithine(Fmoc)-OH; Fmoc-D-Orn(N-Dde)-OH; Nδ-Dde-Nα-Fmoc-D-ornithine
EINECS	Contact for details

Quality Control

Every batch of Dde-D-Orn(Fmoc)-OH is produced under strict quality management systems and undergoes rigorous analytical testing to ensure compliance with high-purity standards for peptide synthesis. Certificates of Analysis (COA) are provided, detailing key parameters such as purity (by HPLC), chiral purity, and moisture content. Our quality commitment supports applications requiring GMP-grade or research-grade materials, with documentation available for audit and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.