Description

Fmoc-(4,Bis( Z)-Guanido)Phe-Oh is a protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of a modified phenylalanine residue with a bis-protected guanidino group, enabling the synthesis of complex peptides with specific biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated or manual assembly of custom peptide sequences.
• Pharmaceutical Research & Development: For constructing peptide-based drug candidates targeting various diseases, where the guanidino functionality is essential for bioactivity.
• Bioconjugation & Probe Development: Serves as a specialized precursor for creating labeled peptides or affinity tags used in biochemical assays and diagnostic tools.
• Academic Research: Used in chemical biology and medicinal chemistry studies to investigate protein-protein interactions and enzyme mechanisms.
• Production of GLP-1 Analogues and Other Therapeutic Peptides: A vital intermediate in the synthesis of peptides where arginine-like properties are needed but with modified stability or selectivity.

Basic Information

Product Name	Fmoc-(4,Bis( Z)-Guanido)Phe-Oh
CAS No.	2044710-17-8
Molecular Formula	C33H36N4O6
Molecular Weight	584.67 g/mol
Synonyms	Fmoc-(4-Bis(Z)-Guanido)Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(benzyloxy)carbonyl]amino]-N'-[(benzyloxy)carbonyl]imidodicarbonimidic diamide-L-phenylalanine; Fmoc-Phe(4-(Bis-Z-guanidino))-OH; Fmoc-4-(N,N'-Bis-Z-guanidino)-L-phenylalanine; Nα-Fmoc-NG,NG'-bis(benzyloxycarbonyl)-L-arginine(4-phenylalanine) derivative; Fmoc-Arg(Pbf)-OH analogue (phenylalanine-based); Protected guanidino phenylalanine building block
EINECS	Contact for details

Quality Control

Our Fmoc-(4,Bis( Z)-Guanido)Phe-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.