Description

Fmoc-D-(4,Bis( Boc)-Guanido)Phe-Oh is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for introducing a side-chain protected arginine-like moiety with a D-configuration into peptide chains, enabling the research and development of novel peptides with enhanced stability and biological activity. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: For constructing peptide-based drug candidates targeting various diseases, including metabolic disorders and oncology.
• Biochemical Research: Used in the study of protein-protein interactions and enzyme mechanisms by incorporating modified arginine analogs.
• Peptidomimetic Development: Serves as a precursor for creating stable, non-hydrolyzable mimics of natural arginine-containing peptides.
• Antibiotic & Antimicrobial Peptide Research: Facilitates the synthesis of novel antimicrobial peptides (AMPs) with potential therapeutic applications.
• GPCR Ligand Synthesis: Employed in the production of peptide ligands for G-protein-coupled receptors (GPCRs).

Basic Information

Product Name	Fmoc-D-(4,Bis( Boc)-Guanido)Phe-Oh
CAS No.	2044709-96-6
Molecular Formula	C36H50N4O9
Molecular Weight	682.81 g/mol
Synonyms	Fmoc-D-4-(N,N'-Bis-Boc-guanidino)phenylalanine; Fmoc-D-(4-(N,N'-di-Boc-guanidino))Phe-OH; N-α-Fmoc-N-ω,ω'-bis(tert-butoxycarbonyl)-D-homoarginine; Fmoc-D-hArg(Boc2)-OH; Fmoc-D-NG,NG'-bis-Boc-homoarginine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]imidazol-1-yl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-(4,Bis( Boc)-Guanido)Phe-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.