Description

Fmoc-Norarg(Me,Pbf)-Oh CAS NO 2044704-60-9 is a protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of modified arginine analogs into peptide chains, enabling advanced research into protein structure and function. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies developing novel peptide-based therapeutics and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides containing modified arginine residues.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide drugs targeting various diseases, where side-chain modification is crucial for activity and stability.
• Biochemical Research: Enables the study of protein-protein interactions and enzyme mechanisms by allowing site-specific incorporation of non-natural amino acids.
• Peptide Library Construction: Facilitates the generation of diverse peptide libraries for high-throughput screening in pharmaceutical and diagnostic applications.
• API Intermediate: Serves as a sophisticated building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for clinical candidates.

Basic Information

Product Name	Fmoc-Norarg(Me,Pbf)-Oh
CAS No.	2044704-60-9
Molecular Formula	C33H45N5O7S
Molecular Weight	655.81 g/mol
Synonyms	Fmoc-Norarg(Me,Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-N-ω'-methyl-norarginine; Fmoc-Norarg(Me,Pbf)-OH (CAS 2044704-60-9); Fmoc-Norarg(Me,Pbf)-OH (2044704-60-9); N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-N-ω'-methyl-norarginine; Fmoc-Norarg(Me,Pbf)-OH, Peptide Synthesis Building Block; N-α-Fmoc-N-ω-(Pbf)-N-ω'-methyl-norarginine
EINECS	Contact for details

Quality Control

Our Fmoc-Norarg(Me,Pbf)-Oh is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive peptide synthesis. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.