Description

(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[(4-Methoxyphenyl)Methylselanyl]Butanoic Acid is a specialized, high-purity selenocysteine derivative designed for advanced peptide synthesis and biochemical research. This compound matters as a critical building block for introducing selenium-containing amino acids into peptides, enabling the study of selenoproteins, redox biology, and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on peptide chemistry, enzyme mimetics, and targeted drug discovery.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected selenocysteine analog for the Fmoc-strategy, enabling the site-specific incorporation of selenium into synthetic peptides.
• Selenoprotein Research: A key precursor for synthesizing peptides that mimic the active sites of selenoenzymes like glutathione peroxidases and thioredoxin reductases.
• Chemical Biology Probes: Used to create labeled or modified peptides for studying protein structure, function, and protein-protein interactions via selenium-specific detection methods.
• Drug Discovery Platforms: Serves as a building block in medicinal chemistry programs targeting oxidative stress pathways and developing novel antioxidant therapies.
• Bioconjugation & Material Science: The reactive carboxylic acid and protected amine functionalities allow for further derivatization and conjugation to surfaces or other biomolecules.

Basic Information

Product Name	(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[(4-Methoxyphenyl)Methylselanyl]Butanoic Acid
CAS No.	2044704-59-6
Molecular Formula	C27H25NO5Se
Molecular Weight	514.45 g/mol
Synonyms	Fmoc-Sec(PMB)-OH; Fmoc-Selenocysteine(4-methoxybenzyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(4-methoxyphenyl)methylselanyl]-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[(4-methoxyphenyl)methylselanyl]butanoic acid; Fmoc-L-Sec(PMB)-OH; Fmoc-Sec(Mob)-OH; Nα-Fmoc-Npmb-seleno-L-cysteine
EINECS	Contact for details

Quality Control

Our (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[(4-Methoxyphenyl)Methylselanyl]Butanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to guarantee enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.