Description

Fmoc-Alg(Z)2-Oh CAS NO 2044703-23-1 is a protected amino acid derivative, specifically an Fmoc- and Z-protected L-α-aminoadipic acid building block. This compound is critically important for the solid-phase peptide synthesis (SPPS) of complex peptides, particularly those requiring the incorporation of the aminoadipic acid residue with orthogonal side-chain protection. It is an essential raw material for research institutions, pharmaceutical developers, and CROs/CMOs engaged in the discovery and production of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc-strategy synthesis of peptides containing aminoadipic acid.
• Pharmaceutical Research & Development: Used in the discovery and preclinical development of novel peptide drugs, hormones, and antimicrobial peptides.
• Bioconjugation & Labeling: Serves as a precursor for creating custom linkers or modified amino acids for peptide-protein conjugates or fluorescent labeling.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Fundamental research tool in biochemistry, medicinal chemistry, and chemical biology for studying protein structure and function.
• Contract Manufacturing: A critical raw material for CMOs producing GMP-grade peptides for clinical trials and commercial supply.

Basic Information

Product Name	Fmoc-Alg(Z)2-Oh
CAS No.	2044703-23-1
Molecular Formula	C31H31NO8
Molecular Weight	545.58 g/mol
Synonyms	Fmoc-L-α-aminoadipic acid δ-benzyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-α-aminoadipic acid 6-benzyl ester; Fmoc-Aad(OBzl)-OH; Fmoc-6-O-benzyl-L-α-aminoadipic acid; Nα-Fmoc-Nδ-Z-L-2,6-diaminoadipic acid (misnomer, but commonly searched); Fmoc-Aad(Z)-OH; Protected L-aminoadipic acid Fmoc derivative; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]hexanedioic acid 6-benzyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Alg(Z)2-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production protocols. Specifications are aligned with the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.