Description

(Cys(Acm)6.12)-Orexin A (Human, Mouse, Rat) is a chemically modified, protected analog of the neuropeptide Orexin A, designed for advanced research applications. This compound is critical for studying the structure-activity relationships and signaling pathways of the orexin system without premature disulfide bond formation or degradation. It is an essential tool for neuroscientists, pharmacologists, and biochemists focused on sleep-wake regulation, energy homeostasis, and neuroendocrine functions. The product is supplied to the highest purity standards to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: Fundamental studies on orexin receptor (OX1R/OX2R) binding, activation, and downstream signaling cascades.
• Pharmacological Development: Used as a reference standard or intermediate in the design and screening of novel orexin receptor agonists and antagonists.
• Metabolic & Sleep Disorder Studies: Investigation into the role of the orexin system in narcolepsy, obesity, and other metabolic syndromes using human, mouse, and rat models.
• Bioconjugation & Probe Synthesis: The Acm-protected cysteine residues allow for selective deprotection and site-specific conjugation with fluorophores, biotin, or other tags for imaging and detection assays.
• Peptide Chemistry & SPPS: Serves as a valuable building block or reference compound in solid-phase peptide synthesis (SPPS) methodology development.
• Antibody Production: Can be used as a hapten or immunogen for generating antibodies specific to modified or protected orexin peptide sequences.

Basic Information

Product Name	(Cys(Acm)6.12)-Orexin A (Human, Mouse, Rat)
CAS No.	2022974-96-3
Molecular Formula	C152H246N50O48S4
Molecular Weight	~3510.1 g/mol
Synonyms	Acetamidomethyl-Cys(6,12)-Orexin A; Orexin A (human, mouse, rat) with Acm-protected cysteines; Hypocretin-1 analog with Cys(Acm); Protected Orexin A peptide; [Cys(Acm)6,12]-Hypocretin-1; OXA Cys(Acm) analog; Orexin A protected disulfide variant; Research peptide 2022974-96-3
EINECS	Contact for details

Quality Control

Every batch of (Cys(Acm)6.12)-Orexin A (Human, Mouse, Rat) is manufactured and analyzed under strict quality management systems. We guarantee high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and peptide content is supplied with each shipment to support your research compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.