Description

Lys-Trp-Lys-(Ser(Glcnac-β-D))-Tau Peptide (388 - 411)-Lys-Lys(Biotinyl) Amide is a sophisticated, biotinylated glycopeptide fragment derived from the tau protein sequence. This compound is specifically engineered for advanced biochemical research, offering a high-affinity tool for isolation, detection, and interaction studies. It is primarily utilized by research scientists and pharmaceutical developers in the fields of neurodegenerative disease research, proteomics, and biomarker discovery. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency for critical experimental applications.

Application

• Biochemical Research: A critical reagent for studying tau protein function, aggregation mechanisms, and post-translational modifications like O-GlcNAcylation.
• Affinity Purification: Utilizes the biotin tag for streptavidin/avidin-based pull-down assays to isolate interacting proteins or antibodies.
• Diagnostic Development: Serves as a precise antigen for the development and validation of immunoassays targeting phosphorylated tau epitopes.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that modulate tau pathology.
• Structural Biology: Provides a defined glycopeptide substrate for NMR, X-ray crystallography, or mass spectrometry studies to elucidate structure-activity relationships.
• Antibody Production & Characterization: Acts as an immunogen or a testing antigen for generating and characterizing site-specific monoclonal and polyclonal antibodies.

Basic Information

Item	Details
Product Name	Lys-Trp-Lys-(Ser(Glcnac-β-D))-Tau Peptide (388 - 411)-Lys-Lys(Biotinyl) Amide
CAS No.	2022974-40-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tau Peptide (388-411) Lys-Lys(Biotinyl) Amide; Biotinylated Tau Glycopeptide; O-GlcNAc Tau Peptide (388-411); Biotin-KWK(Ser(GlcNAc-β-D))-Tau(388-411)-KK-Amide; Tau Protein Fragment 388-411 Biotin Conjugate; Synthetic Glycosylated Tau Peptide; Biotin-Labeled Tau (388-411) Peptide
EINECS	Contact for details

Quality Control

Every batch of our Lys-Trp-Lys-(Ser(Glcnac-β-D))-Tau Peptide (388 - 411)-Lys-Lys(Biotinyl) Amide is synthesized and purified under stringent conditions to ensure the highest standard of purity, sequence accuracy, and correct modification. Our quality control process includes comprehensive analysis by HPLC and Mass Spectrometry to verify identity and purity. Certificates of Analysis (COA) detailing all analytical results are provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. Avoid repeated freeze-thaw cycles of prepared solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Analysis	Within ± 10% of theoretical
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.