Description

Biotinyl-(Gln1)-Orexin A (Human, Mouse, Rat) CAS NO 2022973-13-1 is a biotinylated, modified neuropeptide analog designed for high-affinity binding studies. This compound is a critical tool for researchers investigating the orexin (hypocretin) receptor system, which plays a central role in regulating sleep-wake cycles, appetite, and energy homeostasis. It is primarily utilized in neuroscience, pharmacology, and endocrinology research for applications such as receptor localization, pull-down assays, and signal transduction pathway analysis.

Application

• Receptor Binding & Localization Studies: Used as a high-affinity probe for visualizing and quantifying orexin receptor distribution in tissue sections and cell cultures.
• Pull-Down & Affinity Purification Assays: Facilitates the isolation and identification of orexin receptor complexes and associated proteins due to its biotin tag.
• Signal Transduction Research: Employed to study downstream signaling pathways activated by orexin receptor engagement.
• Drug Discovery & Screening: Serves as a reference compound or tracer in competitive binding assays to evaluate novel orexin receptor agonists or antagonists.
• Neuroscience & Sleep Research: A key reagent for exploring the neurobiological mechanisms underlying sleep disorders like narcolepsy and insomnia.
• Metabolic & Feeding Behavior Studies: Used in research models to investigate the role of the orexin system in appetite regulation and energy balance.

Basic Information

Product Name	Biotinyl-(Gln1)-Orexin A (Human, Mouse, Rat)
CAS No.	2022973-13-1
Molecular Formula	C152H246N48O46S2
Molecular Weight	~3561.0 g/mol
Synonyms	Biotin-Orexin A; Biotinylated Orexin A; Biotinyl-Orexin A; Biotin-Hypocretin-1; Biotinyl-Gln1-Orexin A; [Biotinyl-Gln1]-Orexin A; Orexin A (human, mouse, rat), Biotin-Gln1-labeled; Hypocretin-1 (human, mouse, rat), Biotinylated
EINECS	Contact for details

Quality Control

Our Biotinyl-(Gln1)-Orexin A is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and performance data in standard assay formats. Our quality system supports research requiring reliable and reproducible biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	Confirmed by Mass Spectrometry
Solubility	Soluble in water, DMSO, or aqueous buffers
Biological Activity	Determined by binding assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.