Description

(β-Asp28)-Exenatide CAS NO 2022972-68-3 is a synthetic analogue of the naturally occurring peptide hormone exendin-4, engineered with a specific amino acid substitution at position 28. This modification is designed to enhance its stability and therapeutic profile, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on developing next-generation treatments for metabolic disorders, particularly type 2 diabetes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel glucagon-like peptide-1 (GLP-1) receptor agonists.
• Drug Discovery & Development: Used in preclinical and clinical research to study the effects of peptide modification on pharmacokinetics and pharmacodynamics.
• Metabolic Disorder Research: A vital tool for investigating new therapeutic pathways for diabetes and obesity management.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in peptide manufacturing.
• Bioconjugation Studies: Utilized in research exploring peptide-drug conjugates or labeling for diagnostic purposes.
• Academic Research: Supports fundamental studies in endocrinology and peptide chemistry at universities and research institutes.

Basic Information

Product Name	(β-Asp28)-Exenatide
CAS No.	2022972-68-3
Molecular Formula	C184H282N50O60S
Molecular Weight	4187.6 g/mol
Synonyms	Exenatide (β-Asp28) analogue; [β-Asp28]Exendin-4; (β-Asp28)Exenatide; Lixisenatide related peptide; GLP-1 receptor agonist analogue; Synthetic exendin-4 derivative; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (β-Asp28 variant); BYETTA® analogue
EINECS	Contact for details

Quality Control

Our (β-Asp28)-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances, ensuring it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	≤ 10.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.