Description

(D-Asp28)-Exenatide CAS NO 2022972-67-2 is a synthetic analogue of the glucagon-like peptide-1 (GLP-1) receptor agonist exenatide, featuring a specific D-aspartic acid substitution at position 28. This modification is designed to enhance the peptide's metabolic stability and pharmacokinetic profile, making it a critical intermediate or reference standard in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on developing next-generation therapeutics for metabolic disorders, particularly type 2 diabetes and obesity.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up production of novel GLP-1 receptor agonist therapies.
• Preclinical & Clinical Research: Employed in in vitro and in vivo studies to investigate the structure-activity relationship (SAR), efficacy, and safety profiles of modified exenatide analogues.
• Metabolic Disease Research: A key tool for studying insulin secretion, glucose homeostasis, and weight management mechanisms in metabolic disease models.
• Process Development & Optimization: Used to optimize fermentation, purification, and characterization processes for peptide-based APIs.

Basic Information

Product Name	(D-Asp28)-Exenatide
CAS No.	2022972-67-2
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	Exenatide (D-Asp28); [D-Asp28]-Exenatide; Exendin-4 (D-Asp28) analogue; (D-Asp28) Exendin-4; GLP-1 receptor agonist analogue; AC2993 (D-Asp28); LY2148568 (D-Asp28); Synthetic exenatide derivative
EINECS	Contact for details

Quality Control

Our (D-Asp28)-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents, ensuring it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	≤ 15.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.