Description

(D-Asn28)-Exenatide CAS NO 2022972-66-1 is a synthetic, biologically active peptide analog of exendin-4, specifically modified at the 28th amino acid position with a D-asparagine residue. This modification enhances its metabolic stability and resistance to enzymatic degradation, making it a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by biotechnology firms, pharmaceutical manufacturers, and academic research institutions focused on developing next-generation therapeutics for metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel glucagon-like peptide-1 (GLP-1) receptor agonists and related peptide therapeutics.
• Reference Standard: Used as a high-purity analytical standard for quality control (QC) and method validation in the production of peptide-based drugs.
• Biomedical Research: Employed in preclinical studies to investigate the structure-activity relationships (SAR) of incretin mimetics and their effects on glucose homeostasis.
• Drug Discovery: A vital tool in the discovery and optimization of new anti-diabetic and anti-obesity drug candidates targeting the GLP-1 pathway.
• Metabolic Disorder Studies: Applied in research models to study the mechanisms of type 2 diabetes, obesity, and related metabolic syndromes.
• Process Development: Used in the development and scaling of robust, GMP-compliant synthetic processes for complex peptide APIs.

Basic Information

Product Name	(D-Asn28)-Exenatide
CAS No.	2022972-66-1
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	D-Asparagine(28)-Exendin-4; [D-Asn28]-Exenatide; [D-Asn28]-Exendin-4; (D-Asparagine-28)-Exenatide; Exenatide D-Asn28 analog; D-Asn28 Exendin-4; D-Asparagine(28) Exenatide; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
EINECS	Contact for details

Quality Control

Our (D-Asn28)-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry (MS) for confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.