Description

Tau Peptide (512-525) Amide is a synthetic peptide fragment corresponding to amino acid residues 512-525 of the human tau protein, with a C-terminal amide modification. This sequence-specific peptide is a critical research tool for studying tau protein function, aggregation mechanisms, and its role in neurodegenerative pathologies. It is primarily utilized by researchers and developers in the fields of neuroscience, biochemistry, and pharmaceutical discovery, particularly for antibody development, assay standardization, and investigating tau-related diseases.

Application

• Biomedical Research: Used as a key antigen for the production and characterization of monoclonal and polyclonal antibodies targeting specific epitopes of the tau protein.
• Diagnostic Development: Serves as a critical standard or coating antigen in immunoassays (ELISA, Western Blot) for the detection and quantification of tau protein or specific antibodies in research and clinical samples.
• Mechanistic Studies: Employed in in vitro studies to investigate tau protein aggregation, phosphorylation, and interaction with other biomolecules relevant to neurodegenerative disease pathways.
• Drug Discovery Screening: Utilized in high-throughput screening assays to identify and validate potential therapeutic compounds that modulate tau aggregation or binding.
• Peptide-Based Vaccine Research: Investigated as a potential component in vaccine strategies aimed at generating an immune response against pathological tau forms.
• Control Reagent: Acts as a positive control or reference material in various experimental setups to ensure assay specificity and reproducibility.

Basic Information

Item	Detail
Product Name	Tau Peptide (512-525) Amide
CAS No.	2022956-61-0
Molecular Formula	C73H115N21O20
Molecular Weight	1542.8 g/mol
Synonyms	Tau (512-525) Amide; Human Tau Protein Fragment (512-525) Amide; H-THR-GLN-GLY-ASN-ILE-ASN-ILE-HIS-LYS-PRO-VAL-SER-NH2; TQGNINIHKPVS-NH2; Tau Peptide; Microtubule-associated protein tau (512-525) amide; MAPT (512-525) amide
EINECS	Contact for details

Quality Control

Our Tau Peptide (512-525) Amide is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, amino acid analysis, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight	1542.8 ± 2 Da
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.