Description

(Ser(Poh)22)-Tau Peptide (260-264) Pab Blocking is a chemically synthesized peptide fragment designed for advanced biochemical research. This compound is a critical tool for studying tau protein phosphorylation, a key pathological mechanism in neurodegenerative diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on Alzheimer's disease and related tauopathies.

Application

• Biochemical Research: Used as a specific antigen or blocking agent in immunoassays (e.g., ELISA, Western Blot) to study tau protein epitopes and phosphorylation at serine 22.
• Antibody Development & Validation: Serves as a critical standard for the production, screening, and specificity testing of phospho-tau antibodies.
• Neurodegenerative Disease Modeling: Employed in in vitro studies to investigate the role of specific tau phosphorylation events in disease progression.
• Diagnostic Assay Development: Acts as a key component in the development of sensitive and specific diagnostic tests for detecting pathological tau in biological samples.
• Drug Discovery Screening: Utilized in high-throughput screening platforms to identify potential therapeutic compounds that modulate tau phosphorylation.

Basic Information

Product Name	(Ser(Poh)22)-Tau Peptide (260-264) Pab Blocking
CAS No.	2022956-57-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Phospho-Tau (Ser22) Peptide (260-264); pS22-Tau (260-264) Blocking Peptide; Tau Phosphopeptide (pSer22); Blocking Peptide for anti-phospho-Tau (Ser22) antibody; Microtubule-associated protein tau phosphopeptide; MAPT phosphopeptide (Ser22); Synthetic tau protein fragment (260-264) phosphorylated at Ser22.
EINECS	Contact for details

Quality Control

Our research-grade peptides are produced under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analysis, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, sequence, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	H-KVAVVR(pS)TPPKSPSSAKSRLQT-OH
Single Phosphorylation Site	Confirmed at Serine 22 (Ser22)
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.