Description

Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) is a synthetic peptide fragment corresponding to a specific region of the human tau protein, a key target in neurodegenerative disease research. This high-purity, sequence-specific reagent is critical for advancing fundamental studies into tau biology, aggregation mechanisms, and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, Alzheimer's disease, and related tauopathies.

Application

• Biochemical Research: Used as a substrate or standard in enzymatic assays to study tau phosphorylation, acetylation, and cleavage by various proteases.
• Antibody Development & Validation: Serves as a critical antigen for the production, screening, and characterization of monoclonal and polyclonal antibodies targeting specific tau epitopes.
• In Vitro Aggregation Studies: Essential for investigating the kinetics and conditions of tau fibrillization and oligomerization, key processes in neurodegenerative disease pathology.
• Drug Discovery Screening: Employed in high-throughput and secondary screening assays to identify and characterize small molecules or biologics that modulate tau aggregation or interaction.
• Diagnostic Assay Development: Used as a calibrated reference material in the development of immunoassays (e.g., ELISA) for detecting tau species in biological fluids.
• Structural Biology: Provides material for NMR, X-ray crystallography, and cryo-EM studies to elucidate the structure-function relationship of tau protein domains.

Basic Information

Product Name	Acetyl-Tau Peptide (244-274) (Repeat 1 Domain)
CAS No.	2022956-56-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Acetylated Tau Peptide (244-274); Tau (244-274) peptide, acetylated; Microtubule-associated protein tau fragment 244-274, N-acetyl; Ac-Tau(244-274); Ac-hTau(244-274); Repeat Domain 1 (RD1) Tau Peptide, Acetylated; N-acetyl-Tau244-274; Synthetic tau protein fragment
EINECS	Contact for details

Quality Control

Every batch of Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) is manufactured under strict quality systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, identity, and content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.