Description

Tau Peptide (45-73) (Exon 2/Insert 1 Domain) is a synthetic peptide fragment corresponding to a specific region of the human microtubule-associated protein tau. This sequence is of significant research interest for its role in protein-protein interactions and tauopathies. It serves as a critical reference standard and research reagent for scientists in neuroscience, biochemistry, and pharmaceutical development, enabling studies on tau aggregation, function, and therapeutic targeting.

Application

• Neuroscience Research: Fundamental studies on tau protein biology, including its structure, function, and interaction with microtubules and other neuronal proteins.
• Biomarker Development: Utilized as an antigen or standard in the development of immunoassays (ELISA, Western Blot) for detecting tau and its fragments in biological samples.
• Drug Discovery & Screening: Acts as a key substrate in high-throughput screening assays to identify and characterize potential inhibitors of tau aggregation or modulators of its function.
• Tauopathy Models: Essential for in vitro studies modeling neurodegenerative diseases like Alzheimer's disease, frontotemporal dementia, and chronic traumatic encephalopathy (CTE).
• Antibody Production & Validation: Used for immunizing animals to generate specific anti-tau antibodies and for subsequent validation of antibody specificity.
• Biophysical Studies: Investigation of peptide conformation, stability, and aggregation kinetics using techniques such as circular dichroism (CD), nuclear magnetic resonance (NMR), and fluorescence spectroscopy.

Basic Information

Product Name	Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
CAS No.	2022956-54-1
Molecular Formula	C140H229N43O44S
Molecular Weight	3187.6 g/mol
Synonyms	Tau Protein Fragment (45-73); Human Tau Peptide (45-73); MAPT (45-73); Microtubule-Associated Protein Tau Peptide (45-73); Tau Exon 2/Insert 1 Domain Peptide; Tau (45-73); Synthetic Tau Peptide; Neurofibrillary Tangle-associated Peptide Fragment
EINECS	Contact for details

Quality Control

Our Tau Peptide (45-73) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to quality management principles aligned with research-grade material production.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.