Description

Orexin A (1-15) (Free Acid) CAS NO 2022956-49-4 is a synthetic peptide fragment corresponding to the N-terminal region of the endogenous neuropeptide Orexin A (Hypocretin-1). This compound is a critical research tool for investigating the structure-activity relationships and signaling mechanisms of the orexinergic system. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in metabolic, sleep, and neurological disorder studies.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of orexin receptor (OX1R and OX2R) binding, activation, and downstream signaling pathways.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore model for designing and screening novel orexin receptor agonists or antagonists.
• Metabolic Studies: Applied in research exploring the role of orexin in appetite regulation, energy homeostasis, and feeding behavior.
• Sleep/Wake Cycle Research: Utilized in experimental models to understand the modulation of arousal, wakefulness, and narcolepsy.
• Biochemical Assays: Functions as a competitive ligand in receptor binding assays (RBA) and other in vitro pharmacological test systems.
• Antibody Production & Immunoassays: Acts as an antigen for generating specific antibodies used in ELISA, immunohistochemistry, and other detection methods.

Basic Information

Product Name	Orexin A (1-15) (Free Acid)
CAS No.	2022956-49-4
Molecular Formula	C78H122N24O22S2
Molecular Weight	1771.1 g/mol
Synonyms	Hypocretin-1 (1-15); Orexin-A (1-15); Orexin A Fragment 1-15; Hcrt1 (1-15); Pyr-Gly-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-OH (Disulfide bridge: Cys7-Cys14, Cys8-Cys15); L-Pyroglutamyl-L-prolyl-L-leucyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-α-glutaminyl-L-lysyl-L-threonyl-L-cysteinyl-L-seryl-L-cysteine (cyclic 7-14, 8-15)-disulfide
EINECS	Contact for details

Quality Control

Every batch of Orexin A (1-15) (Free Acid) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade peptides. Comprehensive Certificates of Analysis (COA) are provided, detailing purity, identity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	± 10% of theoretical
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.