Description

Myelin Oligodendrocyte Glycoprotein (35-55) Amide (Rat, Mouse) is a synthetic peptide fragment corresponding to amino acids 35-55 of the myelin oligodendrocyte glycoprotein (MOG) protein, modified with a C-terminal amide group. This peptide is a critical research tool for studying the pathogenesis of autoimmune demyelinating diseases, particularly experimental autoimmune encephalomyelitis (EAE), which serves as a model for multiple sclerosis. It is primarily utilized by neuroscientists, immunologists, and pharmaceutical researchers in academic institutions, biotechnology firms, and contract research organizations (CROs) focused on neuroimmunology and drug discovery.

Application

• Induction of Experimental Autoimmune Encephalomyelitis (EAE): The primary application is to induce EAE in rodent models (rats and mice) for studying the mechanisms of autoimmune-mediated demyelination.
• T-Cell Epitope Mapping: Used to identify and characterize antigen-specific T-cell responses and epitope recognition in neuroinflammatory diseases.
• Immunological Assay Development: Serves as a key antigen in developing and validating assays such as ELISPOT, proliferation assays, and cytokine profiling to measure immune reactivity.
• Vaccine and Therapeutic Evaluation: Employed as a target antigen in preclinical studies to evaluate the efficacy of potential therapeutics, tolerizing vaccines, or immunomodulatory agents for multiple sclerosis.
• Antibody Production and Characterization: Can be used as an immunogen to generate monoclonal or polyclonal antibodies specific to the MOG protein for diagnostic or research purposes.
• Basic Research in Neuroimmunology: Fundamental research tool for investigating the role of MOG-specific immune responses in central nervous system inflammation and demyelination.

Basic Information

Product Name	Myelin Oligodendrocyte Glycoprotein (35-55) Amide (Rat, Mouse)
CAS No.	2022956-48-3
Molecular Formula	C98H155N29O31
Molecular Weight	~2247.5 g/mol
Synonyms	MOG (35-55) Amide; MOG35-55 Amide; Myelin Oligodendrocyte Glycoprotein Peptide (35-55); MOG Peptide Fragment 35-55; MOG p35-55; MOG35-55 (rat, mouse); Experimental Autoimmune Encephalomyelitis Inducing Peptide; Autoantigen MOG (35-55); Ac-MEVGWYRSPFSRVVHLYRNGK-NH2
EINECS	Contact for details

Quality Control

Our peptides are manufactured under strict quality control protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques, with purity typically exceeding 95%. Certificates of Analysis (COA) are provided, detailing results for purity (HPLC), molecular weight confirmation (MS), amino acid analysis, and peptide content. We support research requiring compliance with standards for in-vivo applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Retention time and mass correspond to reference
Purity (HPLC)	≥ 95%
Molecular Weight	2247.5 ± 2 Da
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70%
Solubility	Soluble in water or PBS; consult TDS for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.