Description

(Glu20)-Glucagon (1-29) (Human, Rat, Porcine) is a synthetic peptide analog of glucagon, a key hormone involved in glucose metabolism. This high-purity research-grade compound is critical for advancing studies in endocrinology, diabetes research, and metabolic disorder therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on peptide-based drug discovery and development.

Application

• Biomedical Research: Fundamental studies on glucagon receptor (GCGR) binding, signaling pathways, and hormone action mechanisms.
• Drug Discovery & Development: Serving as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of novel anti-diabetic and metabolic drugs.
• In Vitro & In Vivo Assays: Used in cell-based assays and animal model studies (utilizing human, rat, or porcine analogs) to investigate hyperglycemic effects and liver glucose production.
• Analytical Standard: Employed as a certified reference material in High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) for method development and quality control.
• Peptide Chemistry Studies: Valuable for structure-activity relationship (SAR) studies due to its specific glutamate substitution at position 20.

Basic Information

Product Name	(Glu20)-Glucagon (1-29) (Human, Rat, Porcine)
CAS No.	2022956-46-1
Molecular Formula	C153H225N43O49S
Molecular Weight	3484.7 g/mol
Synonyms	[Glu20]-Glucagon (1-29); Glucagon (1-29), Glu20-substituted; Glucagon analog (Glu20); H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Glu-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH; GCGR agonist analog; Research glucagon peptide
EINECS	Contact for details

Quality Control

Our (Glu20)-Glucagon (1-29) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and residual solvent levels is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.