Description

Nim-Benzyl-D-Histidine CAS NO 2022956-35-8 is a high-purity, non-natural amino acid derivative featuring a benzyl-protected imidazole side chain in the D-configuration. This compound is a critical chiral building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptide-based therapeutics, enzyme inhibitors, and diagnostic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel peptide drugs and enzyme inhibitors.
• Protease Inhibitor Research: Used in the design and synthesis of selective inhibitors targeting histidine-utilizing proteases.
• Peptidomimetic Chemistry: Serves as a constrained, protected histidine analog for constructing stable peptide mimics.
• Chemical Biology Probes: Incorporation into activity-based probes (ABPs) for studying enzyme function and mechanism.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Diagnostic Agent Development: Potential intermediate for radiopharmaceuticals or contrast agents targeting specific biological pathways.

Basic Information

Product Name	Nim-Benzyl-D-Histidine
CAS No.	2022956-35-8
Molecular Formula	C13H15N3O2
Molecular Weight	245.28 g/mol
Synonyms	D-Histidine, N(im)-benzyl-; (R)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid; N(τ)-Benzyl-D-histidine; Nim-Benzyl-D-histidine; Nim-Benzyl-D-histidine; D-Histidine(Nim-benzyl); Benzyl-D-histidine derivative; 1-Benzyl-1H-imidazole-4-propanoic acid, α-amino-, (αR)-
EINECS	Contact for details

Quality Control

Our Nim-Benzyl-D-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.