Description

(3R)-n-{3,6-Dichloro-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl}Piperidin-3-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry, essential for the synthesis of targeted therapeutic agents. Its value lies in its role as a critical building block for novel kinase inhibitors and other small molecule drugs under development. This compound is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the discovery and production of innovative medicines.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potent and selective kinase inhibitors for oncology and inflammatory disease research.
• Drug Discovery & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial scaffold in the multi-step manufacturing process of complex target molecules.
• Biochemical Research: Employed as a tool compound or reference standard in enzymatic assays and biological target validation studies.
• Preclinical Candidate Production: Supplied for the synthesis of compounds required for in-vivo pharmacokinetic and toxicology studies.

Basic Information

Product Name	(3R)-n-{3,6-Dichloro-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl}Piperidin-3-Amine Hydrochloride
CAS No.	2007916-10-9
Molecular Formula	C10H12Cl3N7 • HCl
Molecular Weight	363.62 g/mol (Free base: 327.61)
Synonyms	(3R)-N-(3,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperidin-3-amine hydrochloride; (3R)-3-[(3,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]piperidine hydrochloride; (R)-N-(3,6-dichloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperidin-3-amine HCl; CAS 2007916-10-9; 3,6-Dichloro-4-[(3R)-3-piperidinylamino]-1H-pyrazolo[3,4-d]pyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our (3R)-n-{3,6-Dichloro-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl}Piperidin-3-Amine Hydrochloride is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure high chemical and isomeric consistency. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.