Description

Fmoc-D-His(3-Me)-Oh CAS NO 2002499-17-2 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This high-purity building block is critical for researchers and manufacturers developing novel peptide-based pharmaceuticals and biochemical tools. It is primarily utilized in solid-phase peptide synthesis (SPPS) by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on creating peptides with enhanced stability, bioavailability, or specific biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential construction of complex peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and development of novel therapeutic peptides, including hormone analogs, enzyme inhibitors, and targeted drug candidates.
• Peptidomimetic Design: Incorporation of this modified histidine residue aids in creating peptides with improved metabolic stability and receptor binding affinity.
• Bioconjugation and Probe Development: Serves as a specialized component in the synthesis of labeled peptides for diagnostic imaging, biomarker studies, and biochemical assays.
• Combinatorial Chemistry Libraries: Employed to introduce structural diversity into peptide libraries for high-throughput screening against biological targets.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Fmoc-D-His(3-Me)-Oh
CAS No.	2002499-17-2
Molecular Formula	C₂₂H₂₃N₃O₅
Molecular Weight	409.44 g/mol
Synonyms	Fmoc-D-3-methylhistidine; N-α-Fmoc-D-3-methylhistidine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-methyl-1H-imidazol-4-yl)propanoic acid; Fmoc-D-His(3-Me)-OH; Fmoc-D-3-Me-His-OH; D-3-Methylhistidine Fmoc derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-D-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-D-His(3-Me)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles for active pharmaceutical ingredient (API) intermediates, supporting our commitment to reliable supply and traceability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.