Description

L-Phenylalanine, 3-Chloro-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-Fluoro- is a sophisticated, non-natural amino acid derivative designed for advanced research and development. This compound is a critical building block in the synthesis of complex peptides and modified biomolecules, offering precise chemical functionality for structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions engaged in medicinal chemistry, proteomics, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A key protected amino acid intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry: Used in the research and development of novel peptide-based drugs and bioactive compounds.
• SAR Studies: Enables the investigation of how specific halogen and protecting group modifications affect biological activity and peptide stability.
• Bioconjugation: Serves as a specialized linker or modified residue for creating labeled peptides or peptide-drug conjugates.
• Academic Research: A valuable tool for studying enzyme-substrate interactions, protein folding, and peptide mimetics in university and institutional labs.
• Process Development: Used in scaling up and optimizing synthetic routes for complex peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	L-Phenylalanine, 3-Chloro-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-Fluoro-
CAS No.	2002450-83-9
Molecular Formula	C24H19ClFNO4
Molecular Weight	439.86 g/mol
Synonyms	Fmoc-3-Chloro-2-fluoro-L-phenylalanine; Fmoc-3-Cl-2-F-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-2-fluoro-L-phenylalanine; (2S)-3-(3-Chloro-2-fluorophenyl)-2-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; 3-Chloro-2-fluoro-L-phenylalanine Fmoc derivative; Fmoc-L-Phe(3-Cl-2-F)-OH; Fmoc-3-chloro-2-fluoro-Phe; Fmoc-(3-Cl,2-F)Phe
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), chiral purity, and residual solvent content. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.