Description

5H-Pyrrolo[3,2-d]pyrimidine, 7-Bromo-4-Methoxy-5-((2-(trimethylsilyl)ethoxy)methyl)- is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds to develop novel active pharmaceutical ingredients (APIs) and agrochemicals. Its unique structure, featuring a bromo-substituted pyrrolopyrimidine core protected by a SEM (2-(trimethylsilyl)ethoxymethyl) group, makes it an indispensable intermediate for targeted cross-coupling reactions and further functionalization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for organic electronic materials and specialty polymers.
• Academic & Contract Research: Essential for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO labs.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for commercial API manufacturing.
• Bioconjugation & Probe Synthesis: The bromo moiety allows for efficient labeling and attachment to biomolecules or solid supports.

Basic Information

Product Name	5H-Pyrrolo[3,2-d]pyrimidine, 7-Bromo-4-Methoxy-5-((2-(trimethylsilyl)ethoxy)methyl)-
CAS No.	299916-83-9
Molecular Formula	C13H20BrN3O2Si
Molecular Weight	358.31 g/mol
Synonyms	7-Bromo-4-methoxy-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine; 7-Bromo-4-methoxy-5-SEM-pyrrolo[3,2-d]pyrimidine; 5H-Pyrrolo[3,2-d]pyrimidine, 7-bromo-4-methoxy-5-[(2-(trimethylsilyl)ethoxy)methyl]-; 7-Bromo-4-methoxy-5-(2-trimethylsilylethoxymethyl)-5H-pyrrolo[3,2-d]pyrimidine; SEM-Protected 7-Bromo-4-methoxypyrrolo[3,2-d]pyrimidine; 299916-83-9; Pyrrolopyrimidine SEM ether
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.