Description

(Pro3)-Gastric Inhibitory Polypeptide (Human) CAS NO 299898-52-5 is a synthetic peptide analog of the human gastric inhibitory polypeptide (GIP), a key incretin hormone involved in glucose metabolism. This high-purity research-grade compound is critical for advancing studies in endocrinology and metabolic disease research, particularly for investigating insulin secretion and glucagon-like peptide-1 (GLP-1) interactions. It is an essential tool for pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on diabetes, obesity, and novel therapeutic pathways.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of incretin hormone physiology, receptor binding assays, and signal transduction pathways.
• Drug Discovery & Development: Serves as a key intermediate or biological tool in the screening and development of next-generation therapies for Type 2 diabetes and metabolic syndromes.
• Biochemical Assay Development: Employed in the calibration and validation of immunoassays (ELISA, RIA) and other analytical methods designed to detect and quantify GIP activity.
• Academic & Clinical Research: Facilitates fundamental research into the role of GIP in nutrient homeostasis, β-cell function, and its potential in combination therapies with GLP-1 agonists.
• Diagnostic Manufacturing: Acts as a critical antigen or calibrator in the production of diagnostic kits for measuring GIP levels in clinical and research settings.

Basic Information

Product Name	(Pro3)-Gastric Inhibitory Polypeptide (Human)
CAS No.	299898-52-5
Molecular Formula	C225H344N60O67S
Molecular Weight	4984.6 g/mol
Synonyms	GIP (1-42), human; Gastric Inhibitory Polypeptide, human; Glucose-dependent Insulinotropic Polypeptide, human; GIP, human; (Pro3)hGIP; Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-Arg-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln; 299898-52-5
EINECS	Contact for details

Quality Control

Our (Pro3)-Gastric Inhibitory Polypeptide (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical results to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.