Description

5-[(2-Piperazin-1-Yl-Ethylamino)-Methylene]-Pyrimidine-2,4,6-Trione is a specialized heterocyclic organic compound featuring a uracil (pyrimidinetrione) core functionalized with a piperazine-ethylamino side chain. This molecular architecture makes it a valuable high-purity intermediate for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical manufacturers and contract research organizations (CROs) engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Potential use as a tool compound or precursor in enzymatic studies due to its uracil-derived structure.
• Custom Synthesis: Basis for the preparation of more complex, proprietary molecules for client-specific drug discovery programs.

Basic Information

Product Name	5-[(2-Piperazin-1-Yl-Ethylamino)-Methylene]-Pyrimidine-2,4,6-Trione
CAS No.	299442-86-7
Molecular Formula	C11H17N5O3
Molecular Weight	267.29 g/mol
Synonyms	5-[(2-(Piperazin-1-yl)ethylamino)methylene]pyrimidine-2,4,6(1H,3H,5H)-trione; 5-[(2-Piperazin-1-ylethylamino)methylene]barbituric acid; 5-[(2-(1-Piperazinyl)ethylamino)methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-[(2-Piperazin-1-ylethylamino)methylene]-1,3-diazinane-2,4,6-trione; 299442-86-7; Barbituric acid, 5-[(2-(1-piperazinyl)ethylamino)methylene]-
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support regulatory filings with necessary documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.