Description

4-[(3-Bromophenyl)Amino]-6-Methylcarbonyloxy-7-Methoxyquinazoline is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is of significant commercial interest for its role in the research and development of targeted therapeutic agents, particularly kinase inhibitors. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel drug candidates for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinazoline-based kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a critical precursor in the scale-up and process optimization for potential Active Pharmaceutical Ingredients (APIs).
• Academic Research: Employed in university and institutional labs for medicinal chemistry projects exploring new heterocyclic scaffolds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-[(3-Bromophenyl)Amino]-6-Methylcarbonyloxy-7-Methoxyquinazoline
CAS No.	295330-64-2
Molecular Formula	C₁₇H₁₄BrN₃O₃
Molecular Weight	388.22 g/mol
Synonyms	4-[(3-Bromophenyl)amino]-6-(methoxycarbonyl)-7-methoxyquinazoline; 6-(Methoxycarbonyl)-7-methoxy-4-[(3-bromophenyl)amino]quinazoline; 4-(3-Bromoanilino)-6-methoxycarbonyl-7-methoxyquinazoline; 295330-64-2; UNII-8H8K5F6W6T; 8H8K5F6W6T; BDBM50111657; AKOS005147947; ZINC000004057791
EINECS	Contact for details

Quality Control

Our production of 4-[(3-Bromophenyl)Amino]-6-Methylcarbonyloxy-7-Methoxyquinazoline adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.