Description

1-(6-Chloro-4-Pyrimidinyl)Indoline is a high-purity, advanced pharmaceutical intermediate characterized by its indoline and chloropyrimidine functional groups. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization processes.
• Kinase Inhibitor Synthesis: A key scaffold in the construction of potent and selective kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Biology Probes: Employed in the development of chemical probes to study and modulate biological processes at the molecular level.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacology projects.

Basic Information

Product Name	1-(6-Chloro-4-Pyrimidinyl)Indoline
CAS No.	293292-33-8
Molecular Formula	C13H10ClN3
Molecular Weight	243.69 g/mol
Synonyms	1-(6-Chloro-4-pyrimidinyl)-2,3-dihydro-1H-indole; 1-(6-Chloropyrimidin-4-yl)indoline; 6-Chloro-4-(2,3-dihydro-1H-indol-1-yl)pyrimidine; Indoline, 1-(6-chloro-4-pyrimidinyl)-; 293292-33-8; 1H-Indole, 2,3-dihydro-1-(6-chloro-4-pyrimidinyl)-
EINECS	Contact for details

Quality Control

Our 1-(6-Chloro-4-Pyrimidinyl)Indoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports both research-grade and cGMP-grade requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.