Description

(Met(O)35)-Amyloid β-Protein (25-35) CAS NO 292147-12-7 is a chemically modified peptide fragment of the amyloid beta protein, specifically oxidized at the methionine-35 residue. This modification is critical for studying the role of oxidative stress and methionine sulfoxide in the aggregation and neurotoxicity pathways associated with Alzheimer's disease research. It serves as an essential biochemical tool for neuroscientists, pharmacologists, and biochemists in academic, pharmaceutical, and biotechnology R&D sectors focused on neurodegenerative disorders.

Application

• Neurodegenerative Disease Research: Primary tool for investigating the aggregation kinetics, toxicity, and structural properties of oxidized amyloid beta species in Alzheimer's disease models.
• Drug Discovery & Screening: Used in high-throughput assays to evaluate potential therapeutic compounds designed to inhibit the aggregation or mitigate the toxicity of oxidized amyloid beta peptides.
• Biophysical Studies: Employed in spectroscopic analyses (e.g., NMR, CD, FTIR) and microscopy (e.g., AFM, TEM) to characterize the conformational changes and fibril formation of the oxidized peptide.
• Antibody & Diagnostic Development: Acts as a specific antigen for generating and testing antibodies that selectively recognize oxidized forms of amyloid beta for diagnostic assay development.
• Cellular & Animal Model Studies: Applied in in vitro cell culture and in vivo studies to induce and model oxidative stress-related neuronal damage and synaptic dysfunction.
• Mechanistic Biochemistry: Used to study the enzymatic pathways involving methionine sulfoxide reductases and their role in protein repair and redox regulation in the brain.

Basic Information

Product Name	(Met(O)35)-Amyloid β-Protein (25-35)
CAS No.	292147-12-7
Molecular Formula	C55H84N16O19S
Molecular Weight	1281.4 g/mol
Synonyms	Abeta (25-35) (Met(O)35); Amyloid β-Protein (25-35) oxidized at Met-35; Aβ(25-35) Met35-sulfoxide; H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met(O)-OH; Oxidized Amyloid Beta Peptide (25-35); Aβ25-35 (Met(O)35); β-Amyloid Peptide (25-35), Methionine Sulfoxide; Amyloid β-Peptide (25-35) (human, oxidized)
EINECS	Contact for details

Quality Control

Our (Met(O)35)-Amyloid β-Protein (25-35) is produced and analyzed under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for peptide synthesis and purification, ensuring the product meets the exacting standards required for pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.