Description

H-L-Dap(Fmoc)-Otbu*Hcl is a protected amino acid derivative, specifically an Fmoc-protected L-2,3-diaminopropionic acid tert-butyl ester hydrochloride salt. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a diamino acid residue with orthogonal side-chain protection. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research biochemicals where precise sequence control and side-chain functionality are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides containing 2,3-diaminopropionic acid (Dap) residues.
• Pharmaceutical Research: Used in the development of peptide drugs, hormone analogs, and enzyme inhibitors where Dap is used to introduce branching points, chelating sites, or to modify peptide backbone properties.
• Conjugate Vaccine Development: Serves as a linker or spacer molecule in the synthesis of peptide-carrier protein conjugates for immunological studies and vaccine design.
• Chemical Biology Probes: Incorporation into labeled peptides or affinity tags for studying protein-protein interactions, enzyme activity, and cellular localization.
• Material Science: Building block for the synthesis of peptidomimetics, dendrimers, and other functionalized polymers with specific molecular architectures.

Basic Information

Product Name	H-L-Dap(Fmoc)-Otbu*Hcl
CAS No.	291529-78-7
Molecular Formula	C23H27N2O5 • HCl
Molecular Weight	456.93 g/mol (as free base: 420.47 g/mol)
Synonyms	Fmoc-L-Dap(Boc)-OtBu hydrochloride; Nα-Fmoc-Nβ-Boc-L-2,3-diaminopropionic acid tert-butyl ester hydrochloride; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid tert-butyl ester hydrochloride; Fmoc-Dap(Boc)-OtBu • HCl; Nα-Fmoc-Nβ-Boc-L-α,β-diaminopropionic acid tert-butyl ester hydrochloride; Boc-Dap(Fmoc)-OtBu hydrochloride; L-2,3-Diaminopropionic acid, Nα-Fmoc-Nβ-Boc-, tert-butyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our H-L-Dap(Fmoc)-Otbu*Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.