Description

(Ala11,22,28)-Vip (Human, Bovine, Porcine, Rat) is a synthetic, site-specifically modified analog of the Vasoactive Intestinal Peptide (VIP), a critical neuropeptide and hormone. This engineered peptide is designed for advanced research into VIP receptor (VPAC1/VPAC2) signaling, offering enhanced stability and specificity compared to the native sequence. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic development in fields such as neurobiology, immunology, and oncology. The compound is supplied as a high-purity lyophilized powder to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Fundamental studies on VIP receptor pharmacology, signal transduction pathways, and physiological functions.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of novel therapeutics for inflammatory, neurological, and metabolic disorders.
• In Vitro Assays: Critical reagent in cell-based assays (e.g., cAMP accumulation, calcium flux) for screening and characterizing VPAC1/VPAC2 receptor agonists and antagonists.
• Immunology Studies: Investigation of VIP's role in modulating immune responses, T-cell differentiation, and cytokine production.
• Neuroscience Research: Exploration of neuroprotective effects, neural circuit modulation, and potential in neurodegenerative disease models.
• Diagnostic Development: Potential use in the development of immunoassays and imaging probes targeting VIP receptors, which are overexpressed in certain tumors.

Basic Information

Item	Details
Product Name	(Ala11,22,28)-Vip (Human, Bovine, Porcine, Rat)
CAS No.	291524-04-4
Molecular Formula	C147H237N43O43S
Molecular Weight	3326.8 g/mol
Synonyms	Vasoactive Intestinal Peptide (11-22-28-Ala) analog; [Ala11,22,28]-VIP; VIP analog, alanine-substituted; VIP (human, bovine, porcine, rat) (Ala11,22,28)-; VPAC receptor ligand analog; Research peptide 291524-04-4
EINECS	Contact for details

Quality Control

Every batch of (Ala11,22,28)-Vip is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We guarantee high purity (>95%) as determined by reverse-phase HPLC. Identity is confirmed by mass spectrometry (MS) and amino acid analysis. Our quality commitment ensures the material is suitable for sensitive in vitro and in vivo research applications. A detailed Certificate of Analysis (COA) providing batch-specific data for purity, content, and solvent residues is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent moisture absorption. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.