Description

Fmoc-N-Me-Ser-OH CAS NO 291311-48-3 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound matters because it provides a crucial building block for introducing N-methyl-serine residues, enabling the creation of complex peptides with enhanced metabolic stability and bioavailability. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Incorporation of N-methyl-serine aids in creating peptides with improved membrane permeability and resistance to proteolytic degradation.
• Bioconjugation and Probe Synthesis: Serves as a building block for labeled peptides used in diagnostic assays and biochemical research.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Institutional Research: Fundamental reagent for studies in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-N-Me-Ser-OH
CAS No.	291311-48-3
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-N-methyl-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-serine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-hydroxypropanoic acid; Fmoc-N-Me-L-serine; Fmoc-N-methylserine; N-Fmoc-N-methyl-L-serine; Fmoc-N-Me-Ser-OH; N-α-Fmoc-N-methyl-L-serine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-N-Me-Ser-OH is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Our quality commitment includes comprehensive testing via HPLC, NMR, and MS to verify identity, purity, and chiral integrity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.