Description

4-(2,4-Difluoro-Phenyl)-Piperidine is a high-value fluorinated piperidine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring a difluorophenyl substituent, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and advanced materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of central nervous system (CNS) targeted drugs, kinase inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the stability imparted by the fluorine atoms.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into the design of specialty polymers and liquid crystals to modify thermal and optical properties.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring fluorinated piperidine motifs.

Basic Information

Product Name	4-(2,4-Difluoro-Phenyl)-Piperidine
CAS No.	291289-50-4
Molecular Formula	C11H13F2N
Molecular Weight	197.22 g/mol
Synonyms	4-(2,4-Difluorophenyl)piperidine; 2,4-Difluoro-4-piperidin-1-ylbenzene; 1-(2,4-Difluorophenyl)piperidine; Piperidine, 4-(2,4-difluorophenyl)-; 291289-50-4; 4-(2,4-Difluorophenyl)piperidine hydrochloride (salt form); 4-(2,4-Difluoro-phenyl)-piperidine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated intermediates. Every batch of 4-(2,4-Difluoro-Phenyl)-Piperidine is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting cGMP and ISO 9001 compliant workflows for our partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.