Description

3-Cyclobutoxy-4-Difluoromethoxy-Benzaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzaldehyde core substituted with cyclobutoxy and difluoromethoxy functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the biological activity of the difluoromethoxy moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic electronic materials and liquid crystals due to its rigid, aromatic structure.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Used in exploratory chemistry for novel compound libraries and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Cyclobutoxy-4-Difluoromethoxy-Benzaldehyde
CAS No.	290307-39-0
Molecular Formula	C₁₂H₁₂F₂O₃
Molecular Weight	242.22 g/mol
Synonyms	4-(Difluoromethoxy)-3-cyclobutoxybenzaldehyde; Benzaldehyde, 3-cyclobutoxy-4-(difluoromethoxy)-; 3-Cyclobutyloxy-4-difluoromethoxybenzaldehyde; 290307-39-0; 4-Difluoromethoxy-3-cyclobutoxybenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-Cyclobutoxy-4-Difluoromethoxy-Benzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable supply for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.