Description

1-(4-Fluorophenyl)-1,5-Dihydro-4H-Pyrazolo[3,4-D]Pyrimidin-4-One is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidinone class of heterocyclic compounds. This compound is of significant commercial interest due to its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly kinase inhibitors. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted therapeutic agents, especially protein kinase inhibitors.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and the creation of novel chemical entities for biological screening.
• Biochemical Research: Employed as a reference standard or a tool compound in enzymatic assays and pharmacological studies to investigate specific biological pathways.
• API Manufacturing: Integrated into Good Manufacturing Practice (GMP) production processes for the commercial-scale manufacture of final drug substances.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and process development.

Basic Information

Product Name	1-(4-Fluorophenyl)-1,5-Dihydro-4H-Pyrazolo[3,4-D]Pyrimidin-4-One
CAS No.	289651-72-5
Molecular Formula	C11H7FN4O
Molecular Weight	230.20 g/mol
Synonyms	1-(4-Fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-(4-fluorophenyl)-1,5-dihydro-; 1-(p-Fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; PFPP; Fluorophenyl Pyrazolopyrimidinone; CAS 289651-72-5
EINECS	Contact for details

Quality Control

Our production of 1-(4-Fluorophenyl)-1,5-Dihydro-4H-Pyrazolo[3,4-D]Pyrimidin-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorinating agents. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.