Description

(Pro3)-Dynorphin A (1-11) Amide is a synthetic peptide analog of the endogenous opioid peptide dynorphin A, specifically designed for enhanced stability and research utility. This compound is a critical tool for investigating the kappa opioid receptor (KOR) system, which plays a significant role in pain modulation, stress response, and neuropsychiatric conditions. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers engaged in advanced neuropharmacology and peptide-based drug discovery programs.

Application

• Neuroscientific Research: As a selective kappa opioid receptor (KOR) ligand for studying pain pathways, addiction mechanisms, and stress-related behaviors.
• Pharmacology Development: Serving as a reference standard and lead compound in the development of novel analgesic and neuroprotective agents.
• Biochemical Assays: Used in receptor binding studies, functional cellular assays (e.g., cAMP inhibition), and signal transduction research.
• Academic & Institutional Studies: Fundamental research into the dynorphinergic system and its implications in depression, epilepsy, and other CNS disorders.
• Peptide Chemistry: A model compound for studying structure-activity relationships (SAR) and the effects of proline substitution on peptide conformation and stability.

Basic Information

Product Name	(Pro3)-Dynorphin A (1-11) Amide
CAS No.	289636-76-6
Molecular Formula	C61H94N18O14
Molecular Weight	1279.5 g/mol
Synonyms	Dynorphin A (1-11) amide, [Pro3]-Dynorphin A (1-11) amide; [Pro3]-Dyn A (1-11) amide; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2; (Pro3)-Dynorphin A (1-11)-NH2; Dynorphin A Fragment 1-11 Amide (Pro3 analog)
EINECS	Contact for details

Quality Control

Our (Pro3)-Dynorphin A (1-11) Amide is manufactured under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for peptide synthesis, and our quality system is designed to meet the rigorous demands of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.