Description

(D-Glu5,D-Trp7,9,10)-Substance P (5-11) is a synthetic, biologically active peptide fragment and a potent, selective antagonist of the neurokinin-1 (NK1) receptor. This compound is a critical research tool for studying the role of Substance P in pain signaling, neurogenic inflammation, and various central nervous system processes. It is essential for pharmaceutical R&D, academic research, and the development of novel therapeutic agents targeting neurokinin pathways.

Application

• Neuroscience Research: A key pharmacological tool for investigating the physiological and pathological roles of Substance P and NK1 receptor signaling in the central and peripheral nervous systems.
• Pain & Inflammation Studies: Used in preclinical models to study neurogenic inflammation, migraine, arthritis, and chronic pain pathways due to its potent NK1 receptor antagonism.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the screening and development of new NK1 receptor antagonists for therapeutic applications.
• Cell Signaling & Molecular Biology: Employed in in vitro assays to elucidate intracellular signaling cascades activated by the NK1 receptor.
• Psychopharmacology Research: Utilized in studies exploring the link between neurokinin systems and conditions such as stress, anxiety, depression, and emesis (nausea/vomiting).

Basic Information

Product Name	(D-Glu5,D-Trp7,9,10)-Substance P (5-11)
CAS No.	289632-61-7
Molecular Formula	C58H78N16O13
Molecular Weight	1191.4 g/mol
Synonyms	D-Glu5,D-Trp7,9,10-Substance P (5-11); [D-Glu5,D-Trp7,9,10]-SP(5-11); Substance P (5-11) antagonist; NK1 Receptor Antagonist (D-Glu5,D-Trp7,9,10); Arg-Pro-Lys-Pro-D-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2; [D-Gln5, D-Trp7,9,10] Substance P (5-11); SP (5-11) Antagonist
EINECS	Contact for details

Quality Control

Every batch of (D-Glu5,D-Trp7,9,10)-Substance P (5-11) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A detailed Certificate of Analysis (COA) including HPLC purity, MS confirmation, and amino acid analysis is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.