Description

(S)-n-Fmoc-2-(3'-Butenyl)Alanine is a high-purity, non-proteinogenic amino acid derivative featuring a versatile butenyl side chain and an Fmoc-protected amine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise introduction of structural diversity and specific functionalities into peptide sequences. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Incorporates hydrophobic and reactive alkene functionalities to mimic protein structures and create new bioactive molecules.
• Bioconjugation: The terminal alkene group serves as a handle for site-specific modifications via click chemistry (e.g., thiol-ene reactions).
• Chemical Biology: Employed in the synthesis of labeled peptides for studying protein-protein interactions and cellular processes.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and creating custom peptide libraries.

Basic Information

Product Name	(S)-n-Fmoc-2-(3'-Butenyl)Alanine
CAS No.	288617-72-1
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-(S)-2-(3-Butenyl)alanine; Fmoc-Butenyl-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-buten-2-yl-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(but-3-en-1-yl)acetic acid; Fmoc-L-2-(3-Butenyl)alanine; Nα-Fmoc-L-2-(3'-butenyl)alanine; Fmoc-3-butenyl-L-Ala-OH
EINECS	Contact for details

Quality Control

Every batch of (S)-n-Fmoc-2-(3'-Butenyl)Alanine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for demanding research and cGMP manufacturing applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for HPLC purity, chiral purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.