Description

n-(9-Fluorenylmethoxycarbonyl)-L-Aspartic-15N Acid is a stable isotope-labeled derivative of the amino acid aspartic acid, protected with the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is essential for advanced peptide synthesis, particularly in Solid-Phase Peptide Synthesis (SPPS), where it enables the precise incorporation of a nitrogen-15 (15N) label. It is a critical building block for researchers and manufacturers in pharmaceutical development, proteomics, and metabolic research who require isotopically labeled peptides for mass spectrometry, NMR spectroscopy, and tracer studies.

Application

• Isotope-Labeled Peptide Synthesis: Primary building block for introducing a 15N-labeled aspartic acid residue into custom peptides for research and diagnostic applications.
• Pharmaceutical Research & Development: Used in the synthesis of isotopically labeled drug candidates, metabolites, and internal standards for pharmacokinetic and bioanalytical studies.
• Proteomics and Biomarker Discovery: Enables the preparation of stable isotope-labeled peptides as internal standards for accurate quantification via mass spectrometry (e.g., SRM/MRM, SILAC).
• NMR Spectroscopy Studies: Provides a site-specific 15N label for structural and dynamic analysis of peptides and proteins using nuclear magnetic resonance.
• Metabolic Pathway Tracing: Serves as a precursor in studies investigating amino acid metabolism and protein turnover in biological systems.
• GMP-grade API Intermediate: Potential use in the controlled synthesis of active pharmaceutical ingredients (APIs) requiring isotopic labeling for clinical trials.

Basic Information

Product Name	n-(9-Fluorenylmethoxycarbonyl)-L-Aspartic-15N Acid
CAS No.	287484-33-7
Molecular Formula	C19H17NO6 (15N)
Molecular Weight	355.34 g/mol (for 15N isotopologue)
Synonyms	Fmoc-L-Aspartic-15N Acid; Fmoc-Asp(15N)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-15N-butanedioic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic-15N acid; Fmoc-Asp-OH (15N); Fmoc-DL-Aspartic-15N Acid (racemic mixture); Fmoc-Aspartic Acid-15N
EINECS	Contact for details

Quality Control

Our n-(9-Fluorenylmethoxycarbonyl)-L-Aspartic-15N Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, isotopic enrichment, and chiral integrity. We provide a detailed Certificate of Analysis (COA) that includes data for assay, isotopic purity, chiral purity, and impurity profile. Our quality commitment supports applications requiring GMP, ISO, or research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (15N)	≥ 98 atom % 15N
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.