Description

Suc-Ala-Leu-Pro-Phe-Oh CAS NO 287379-73-1 is a synthetic peptide derivative, specifically a succinylated pentapeptide amide. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a model substrate or intermediate in the study of enzymatic processes, particularly those involving proteases like chymotrypsin or subtilisin. It serves as a critical building block for researchers and manufacturers in the fields of peptide synthesis, medicinal chemistry, and proteomics, where precise molecular structure and high purity are paramount for reliable experimental and developmental outcomes.

Application

• Protease Substrate: Used as a specific chromogenic or fluorogenic substrate for studying the kinetics and specificity of serine proteases, including chymotrypsin and subtilisin.
• Peptide Synthesis Intermediate: Serves as a key protected fragment or precursor in the solid-phase or solution-phase synthesis of larger, more complex bioactive peptides.
• Biochemical Research: Employed in enzymatic assay development and high-throughput screening (HTS) platforms to identify and characterize protease inhibitors for drug discovery.
• Medicinal Chemistry: Acts as a pharmacophore model for designing and optimizing novel peptide-based therapeutics targeting specific proteolytic pathways.
• Quality Control Standard: Utilized as a reference standard in analytical laboratories to calibrate instruments and validate methods for peptide analysis (e.g., HPLC, MS).
• Enzyme Mechanism Studies: Provides insights into enzyme-substrate interactions and catalytic mechanisms due to its well-defined cleavage site.

Basic Information

Product Name	Suc-Ala-Leu-Pro-Phe-Oh
CAS No.	287379-73-1
Molecular Formula	C30H44N6O9
Molecular Weight	632.71 g/mol
Synonyms	Succinyl-Ala-Leu-Pro-Phe-amide; Suc-ALPF-NH2; N-Succinyl-Alanyl-Leucyl-Prolyl-Phenylalaninamide; N-Succinyl-Ala-Leu-Pro-Phe-NH2; Suc-Ala-Leu-Pro-Phe-NH2; ALPF Peptide Substrate; Suc-ALPF-Oh; Protease Substrate Suc-ALPF
EINECS	Contact for details

Quality Control

Our Suc-Ala-Leu-Pro-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), amino acid analysis, and mass spectrometry (MS) confirmation are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For extended storage under inert atmosphere, contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.