Description

L-Alanine-n-Fmoc (1-13C) CAS NO 286460-67-1 is a stable isotope-labeled derivative of the amino acid alanine, specifically enriched with carbon-13 at the 1-position and protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group on the nitrogen. This compound is essential for advanced research and development in fields requiring precise molecular tracking and analysis. It is primarily utilized by pharmaceutical researchers, biochemists, and contract research organizations (CROs) involved in peptide synthesis, metabolic studies, and the development of novel diagnostics and therapeutics.

Application

• Isotope-Labeled Peptide Synthesis: As a key building block in Solid-Phase Peptide Synthesis (SPPS) for incorporating a carbon-13 label into specific positions within synthetic peptides.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to track the incorporation and fate of alanine in biochemical pathways using techniques like NMR or Mass Spectrometry.
• Proteomics and Biomarker Research: Enables the development of internal standards for the accurate quantification of peptides and proteins via mass spectrometry-based proteomic workflows.
• Pharmaceutical R&D: Critical for the research and development of isotope-labeled drug candidates, aiding in pharmacokinetic, pharmacodynamic, and absorption, distribution, metabolism, and excretion (ADME) studies.
• Structural Biology: Facilitates NMR spectroscopy studies of protein structure, dynamics, and interactions by providing site-specific isotopic labeling.
• Academic Research: Serves as a fundamental reagent in university and institutional labs for cutting-edge research in biochemistry, chemical biology, and medicinal chemistry.

Basic Information

Item	Details
Product Name	L-Alanine-n-Fmoc (1-13C)
CAS No.	286460-67-1
Molecular Formula	C18H1713CNO4
Molecular Weight	~311.74 g/mol
Synonyms	Fmoc-L-Alanine-1-13C; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]propanoic-1-13C acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine-1-13C; N-Fmoc-L-alanine-1-13C; Fmoc-Ala-1-13C-OH; Fmoc-L-Ala-1-13C; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoic-1-13C acid
EINECS	Contact for details

Quality Control

Our L-Alanine-n-Fmoc (1-13C) is manufactured under strict quality control protocols to ensure the highest standards of isotopic and chemical purity, essential for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (13C)	≥99 atom %
Optical Rotation	[α]D20: -20.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.