Description

7-Methoxy-6-Benzyloxyquinazolin-4-One is a high-purity quinazolinone derivative, a crucial advanced pharmaceutical intermediate. This compound matters for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers engaged in the development of targeted cancer therapies and other specialized medicinal compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of tyrosine kinase inhibitors and other targeted therapeutic agents.
• Oncology Drug Research: Serves as a core scaffold for developing novel anti-cancer compounds in preclinical and clinical research stages.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex drug molecules.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and new molecular entity design.
• Custom Synthesis: A starting material for the custom synthesis of labeled compounds (e.g., deuterated, C13) for metabolic and pharmacokinetic studies.

Basic Information

Product Name	7-Methoxy-6-Benzyloxyquinazolin-4-One
CAS No.	286371-64-0
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.30 g/mol
Synonyms	4(3H)-Quinazolinone, 6-(benzyloxy)-7-methoxy-; 6-Benzyloxy-7-methoxyquinazolin-4(3H)-one; 7-Methoxy-6-benzyloxy-4(3H)-quinazolinone; 6-(Benzyloxy)-7-methoxy-4(3H)-quinazolinone; 286371-64-0; Quinazolin-4-one, 6-(benzyloxy)-7-methoxy-
EINECS	Contact for details

Quality Control

Our 7-Methoxy-6-Benzyloxyquinazolin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.