Description

L-Alanine-3,3,3-D3-n-Fmoc is a deuterium-labeled, N-Fmoc protected derivative of the amino acid L-alanine, specifically designed for advanced research and development. This compound is a critical building block in the synthesis of isotopically labeled peptides, enabling precise studies in mass spectrometry, metabolic research, and structural biology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in proteomics and drug discovery.

Application

• Isotope-Labeled Peptide Synthesis: As a deuterated precursor for solid-phase and solution-phase peptide synthesis to create internal standards for mass spectrometry.
• Metabolic Pathway Tracing: Used in biochemical research to track the incorporation and fate of amino acids in metabolic studies using techniques like LC-MS.
• Structural Analysis: Aids in Nuclear Magnetic Resonance (NMR) spectroscopy studies by providing site-specific deuterium labeling to simplify complex spectra.
• Proteomics Research: Essential for the development of quantitative proteomics methods, such as SILAC (Stable Isotope Labeling by Amino acids in Cell culture), to measure protein expression and turnover.
• Pharmaceutical Development: Employed in the discovery and development stages of peptide-based therapeutics to study pharmacokinetics, metabolism, and stability.

Basic Information

Product Name	L-Alanine-3,3,3-D3-n-Fmoc
CAS No.	284665-07-2
Molecular Formula	C₁₈H₁₄D₃NO₄
Molecular Weight	314.35 g/mol
Synonyms	Fmoc-L-alanine-d3; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]propanoic-3,3,3-d3 acid; Fmoc-Ala(D3)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine-3,3,3-d3; N-Fmoc-L-alanine-3,3,3-d3; L-Alanine-3,3,3-d3, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3,3-trideuteriopropanoic acid
EINECS	Contact for details

Quality Control

Our L-Alanine-3,3,3-D3-n-Fmoc is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation), chiral purity, and residual solvent content. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your critical research programs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.