Description

n-Fmoc-3-Amino-3-m-Tolyl-Propionic Acid is a protected amino acid derivative, specifically engineered for solid-phase peptide synthesis (SPPS). This compound matters as a crucial building block for the controlled introduction of a non-natural, meta-substituted phenylalanine analog into peptide chains, enabling the development of novel bioactive peptides and peptidomimetics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on drug discovery, particularly in creating targeted therapeutics, enzyme inhibitors, and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs and therapeutic agents.
• Peptidomimetic Design: Incorporates a meta-tolyl side chain to mimic natural amino acids and enhance peptide stability, bioavailability, or receptor binding affinity.
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled or modified peptides used to study protein-protein interactions and biological pathways.
• API Intermediate: Acts as a critical intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Academic & Contract Research: Essential for research in medicinal chemistry, biochemistry, and molecular biology within universities and CROs.

Basic Information

Product Name	n-Fmoc-3-Amino-3-m-Tolyl-Propionic Acid
CAS No.	284492-06-4
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-3-Amino-3-(3-methylphenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(3-methylphenyl)propanoic Acid; 3-[(9-Fluorenylmethoxycarbonyl)amino]-3-(3-methylphenyl)propionic Acid; Fmoc-3-Amino-3-(m-tolyl)propionic Acid; Fmoc-DL-3-(3-Methylphenyl)-β-alanine; (R,S)-3-[(Fmoc)amino]-3-(3'-methylphenyl)propionic Acid; 3-(Fmoc-amino)-3-(3-methylphenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide high-purity grades suitable for pharmaceutical research and peptide synthesis. Every batch is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.