Description

Ac-His-Gly-His-Nhme CAS NO 283167-37-3 is a synthetic tetrapeptide derivative featuring a histidine-rich sequence, which is of significant interest in biochemical and pharmaceutical research. This compound is primarily utilized as a key intermediate or a model substrate in the development of enzyme inhibitors, metal chelators, and diagnostic agents. It is essential for researchers and manufacturers in the fields of proteomics, peptide-based drug discovery, and diagnostic assay development who require high-purity, well-characterized building blocks.

Application

• Biochemical Research: Used as a model peptide substrate for studying enzyme kinetics, particularly for proteases and metalloenzymes.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of more complex therapeutic peptides targeting various diseases.
• Diagnostic Development: Employed in the design and calibration of diagnostic kits and assays that rely on specific peptide-protein interactions.
• Metal Chelation Studies: Acts as a ligand in research focused on metal ion binding and transport due to its histidine residues.
• Proteomics & Biomarker Discovery: Utilized as a standard or reference compound in mass spectrometry and chromatography-based analytical workflows.
• Academic & Contract Research: Supplied to universities and CROs for fundamental research in biochemistry and medicinal chemistry.

Basic Information

Product Name	Ac-His-Gly-His-Nhme
CAS No.	283167-37-3
Molecular Formula	C21H30N10O5
Molecular Weight	502.53 g/mol
Synonyms	Acetyl-Histidyl-Glycyl-Histidyl-Methylamide; N-Acetyl-L-histidylglycyl-L-histidine methylamide; Ac-His-Gly-His-NHMe; Ac-HGH-NHMe; Ac-HGH-OMe (common abbreviation); Acetyl-His-Gly-His-N-methylamide; L-Histidine, N-acetyl-L-histidylglycyl-, methylamide; Tetrapeptide inhibitor analog
EINECS	Contact for details

Quality Control

Our Ac-His-Gly-His-Nhme is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, MS, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.