Description

n-Fmoc-3-Iodo-L-Alanine tert-Butyl Ester is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the site-specific introduction of iodine atoms into peptide chains, enabling advanced research in medicinal chemistry and bioconjugation. It is primarily utilized by pharmaceutical R&D teams, CROs, and academic laboratories focused on developing novel peptide-based therapeutics, imaging agents, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of 3-iodoalanine residues into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide analogs for structure-activity relationship (SAR) studies and the development of novel bioactive compounds.
• Bioconjugation & Radiolabeling: The iodine atom serves as a handle for further functionalization, including radioiodination for PET imaging or attachment of other molecules via cross-coupling reactions.
• Chemical Biology Research: Enables the study of protein structure, function, and interactions through the site-specific introduction of heavy atoms or chemical tags.
• Production of Custom Peptides: Essential raw material for CMOs and specialized suppliers producing non-standard, iodinated peptides for clients.

Basic Information

Product Name	n-Fmoc-3-Iodo-L-Alanine tert-Butyl Ester
CAS No.	282734-33-2
Molecular Formula	C₂₂H₂₄INO₄
Molecular Weight	517.34 g/mol
Synonyms	(2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-iodo-2-methylpropanoic acid tert-butyl ester; Fmoc-3-Iodo-L-Ala-OtBu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-alanine tert-butyl ester; tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-alaninate; Fmoc-3-I-Ala-OtBu; Fmoc-L-3-Iodoalanine tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Iodo-L-Alanine tert-Butyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.