Description

3-(Fmoc-Amino)-4-Methylpentanoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in providing a sterically hindered, branched-chain amino acid building block with orthogonal protection, enabling the precise construction of complex peptides. This compound is critically needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds. Its reliable quality ensures reproducibility and efficiency in advanced synthetic workflows.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Peptidomimetic Design: Incorporates a branched, hydrophobic side chain to mimic protein structures and enhance metabolic stability in drug design.
• Bioconjugation and Labeling: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter groups.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening.
• Academic & Industrial Research: Fundamental reagent for studying protein-protein interactions, signal transduction, and developing new synthetic methodologies.

Basic Information

Product Name	3-(Fmoc-Amino)-4-Methylpentanoic Acid
CAS No.	282524-93-0
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-Leu-OH(3); 4-Methyl-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]pentanoic Acid; 3-[(Fmoc)amino]-4-methylpentanoic Acid; Fmoc-3-amino-4-methylpentanoic acid; N-α-Fmoc-leucine; N-Fmoc-leucine; Fmoc-Leu; (3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic Acid
EINECS	Contact for details

Quality Control

Our 3-(Fmoc-Amino)-4-Methylpentanoic Acid is manufactured under strict quality systems to ensure it meets the exacting standards required for peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting identity, assay, and impurity profiles to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.