Description

H-Ala-D-Gln-Oh CAS NO 281660-34-2 is a synthetic dipeptide derivative, specifically the D-isomer of glutamine coupled with L-alanine. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or building block for more complex peptide-based therapeutics. It serves as a crucial component for researchers and manufacturers in the life sciences sector who require high-purity, stereochemically defined peptide fragments. Its primary value lies in enabling the synthesis of novel peptides with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the solid-phase or solution-phase synthesis of complex therapeutic peptides and peptidomimetics.
• Research & Development: Used in academic and industrial laboratories for studying peptide structure-activity relationships (SAR), metabolism, and stability.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its amino and carboxyl functionalities.
• Protease Substrate Analog: Potential use as a substrate or inhibitor in enzymatic studies targeting specific proteases that recognize alanine-glutamine sequences.
• Nutraceutical Precursor: May be investigated as a precursor for specialized amino acid supplements, given the role of glutamine in metabolism.

Basic Information

Product Name	H-Ala-D-Gln-Oh
CAS No.	281660-34-2
Molecular Formula	C8H15N3O4
Molecular Weight	217.22 g/mol
Synonyms	L-Alanyl-D-glutamine; D-Glutamine, L-alanyl-; Ala-D-Gln; H-L-Ala-D-Gln-OH; (2R)-2-[[(2S)-2-aminopropanoyl]amino]-4-carbamoylbutanoic acid; Alanyl-D-glutamine; D-Gln-L-Ala; N-(L-Alanyl)-D-glutamine
EINECS	Contact for details

Quality Control

Our H-Ala-D-Gln-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation or clumping. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-Gln
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.