Description

H-Arg-Trp-NH₂ 2 HCl is a high-purity, protected dipeptide derivative, specifically the dihydrochloride salt of the arginyl-tryptophan amide. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS) and pharmaceutical research, offering a protected side chain for the arginine residue. It is essential for researchers and manufacturers developing bioactive peptides, peptide hormones, and novel therapeutic agents. The product is supplied to ensure consistent quality and reliable performance in demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled assembly of longer peptide chains in automated synthesizers.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs targeting various receptors and biological pathways.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide conjugates with dyes, tags, or other molecules for diagnostic and research purposes.
• Biochemical Research: Employed in structure-activity relationship (SAR) studies to understand the role of specific amino acid sequences in protein function.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in peptide production.
• Cosmeceutical Peptides: A potential raw material for the synthesis of bioactive peptides used in advanced skincare formulations.

Basic Information

Product Name	H-Arg-Trp-NH₂ 2 HCl
CAS No.	281659-95-8
Molecular Formula	C17H27N7O2 · 2HCl
Molecular Weight	442.36 g/mol (free base: 361.45 g/mol)
Synonyms	H-Arg-Trp-NH₂ Dihydrochloride; Arg-Trp Amide Dihydrochloride; L-Arginyl-L-tryptophanamide Dihydrochloride; Nα-H-Arg-Trp-NH₂ · 2HCl; RWA Dihydrochloride; NG-Nitro-L-arginyl-L-tryptophanamide Dihydrochloride (if applicable); Protected Arg-Trp Dipeptide; Peptide Synthesis Building Block Fmoc-Arg(Pbf)-Trp-NH₂ (precursor form)
EINECS	Contact for details

Quality Control

Our H-Arg-Trp-NH₂ 2 HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric purity, and identity confirmation by mass spectrometry (MS) and infrared (IR) spectroscopy. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure the material meets the stringent requirements for pharmaceutical research and GMP-compliant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Assay (Anhydrous Basis)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.