Description

Fmoc-3-(3'-Quinolyl)-L-Alanine is a specialized, non-proteinogenic amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a unique quinoline-containing side chain into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and chemical probes where structural complexity and specific aromatic interactions are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research: Used to synthesize peptide candidates for drug discovery, particularly targeting protein-protein interactions where the quinoline moiety can contribute to binding affinity.
• Chemical Biology & Probe Development: Incorporation into peptides designed as fluorescent tags, enzyme inhibitors, or molecular probes due to the photophysical properties of the quinoline group.
• Material Science: Potential use in creating functionalized surfaces or bio-conjugates with specific aromatic characteristics.
• Academic Research: Essential for studying peptide structure-activity relationships (SAR) and developing novel biomimetic compounds.

Basic Information

Product Name	Fmoc-3-(3'-Quinolyl)-L-Alanine
CAS No.	281655-61-6
Molecular Formula	C28H22N2O4
Molecular Weight	450.49 g/mol
Synonyms	Fmoc-3-(3-Quinolyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(quinolin-3-yl)-L-alanine; Fmoc-3-Quinolyl-L-alanine; Fmoc-L-3-(3-Quinolyl)alanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(quinolin-3-yl)propanoic acid; Nα-Fmoc-3-(3-quinolyl)-L-alanine; Fmoc-3-(3-Quin)-L-Ala-OH; Fmoc-3-(3-Quinolyl)alanine
EINECS	Contact for details

Quality Control

Our Fmoc-3-(3'-Quinolyl)-L-Alanine is manufactured under strict quality control protocols to ensure high purity and consistency for sensitive research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.